Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves

• Published in: Materials today communications 2024-06, Vol.39, p.109357, Article 109357
• Main Authors: Wei, Sailong, Wu, Jiangjie, Gu, Xiaokai, Shen, Sufen, Ma, Meng, Shi, Yanqin, He, Huiwen, Zhu, Yulu, Chen, Si, Wang, Xu
• Format: Article
• Language: English
• Subjects: Biomedical; Controllable; Heart valve; Polyurethane; Silicon-based
• ISSN: 2352-4928; 2352-4928
• DOI: 10.1016/j.mtcomm.2024.109357

Polyurethane have the advantages of convenient structural design, low production cost, and excellent mechanical compatibility, and is expected to be used as a polymer heart valve material. However, its development in biomaterials is limited because it is prone to hydrolysis and coagulation after long-term implantation in organisms. In this study, "PEG-MDI-PEG" macromolecular diol was prepared by structural design of the soft segment of polyurethane. Copolymerization with telechelic α,ω-bis(6-hydroxyethoxypropyl)-PDMS as mixed soft segment, prepolymer solution was prepared by solution polymerization, and the biocompatibility of silicone-based polyurethane obtained by casting was characterized. By adjusting the feed ratio to control the silicon content in the copolymer, when the silicon content was 60 %, the protein adsorption capacity was 75 % lower than that of unmodified polyurethane, and the cell activity was more than 80 %, which was a useful characteristic for silicon-based polyurethane as a potential polymer valve material. [Display omitted]