Effects of sarpogrelate on blood viscosity

The objective of the present study was to evaluate the effects and safety of sarpogrelate hydrochloride (sarpogrelate) in patients with elevated blood viscosity (BV), after 12 and 24 weeks of twice (BID) or thrice (TID) daily administrations of sarpogrelate (100 mg). The participants received oral s...

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Bibliographic Details
Published in:Microvascular research 2023-01, Vol.145, p.104439, Article 104439
Main Authors: Yum, Keun-Sang, Kang, Sung-Goo, Lee, Jeong-Won, Cho, Young I.
Format: Article
Language:English
Subjects:
Blood Viscosity
Elevated viscosity
Female
Hemorheology
Humans
Male
Platelet Aggregation Inhibitors - pharmacology
Sarpogrelate, microcirculation, microvascular disease, female
Serotonin Antagonists - pharmacology
Serotonin Antagonists - therapeutic use
Succinates - adverse effects
Whole blood viscosity
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Summary:The objective of the present study was to evaluate the effects and safety of sarpogrelate hydrochloride (sarpogrelate) in patients with elevated blood viscosity (BV), after 12 and 24 weeks of twice (BID) or thrice (TID) daily administrations of sarpogrelate (100 mg). The participants received oral sarpogrelate administration for 24 weeks and visited the hospital every 12 ± 2 week for blood viscosity measurements at shear rates of 5 and 300 s−1. The BV measured at shear rate of 5 s−1 in male patients decreased significantly from 18.91 cP at the baseline to 16.3 cP after 24 weeks of sarpogrelate administration (13.6 % drop, p 
ISSN:0026-2862
1095-9319
DOI:10.1016/j.mvr.2022.104439