Cryptococcal meningitis in a non-HIV patient with solid organ transplantation

Cryptococcal meningitis (CM) is often associated with human immunodeficiency virus (HIV). Recently, this microorganism has been increasingly identified in HIV-negative patients. CM cases are encountered in HIV-negative individuals, especially secondary to liver disease, solid organ transplantation (...

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Bibliographic Details
Published in:Journal de mycologie médicale 2023-08, Vol.33 (3), p.101388, Article 101388
Main Authors: Ugur, Mediha, Cetin, Sinan, Uzunoglu, Emel, Saglam, Mustafa, Mutlu, Fatma, Koc, Ayse Nedret
Format: Article
Language:English
Subjects:
Cryptococcal meningitis
Non-HIV patient
Solid organ transplantation
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Summary:Cryptococcal meningitis (CM) is often associated with human immunodeficiency virus (HIV). Recently, this microorganism has been increasingly identified in HIV-negative patients. CM cases are encountered in HIV-negative individuals, especially secondary to liver disease, solid organ transplantation (SOT), tuberculosis, lymphoproliferative diseases with T-cell-mediated immunological disorders, long-term corticosteroid use, malignancies, diabetes mellitus, and sarcoidosis. Our patient is an HIV-negative, SOT case with CM. It should be considered that CM can also occur in HIV-negative patients. As in our case, patients receiving long-term immunosuppressive therapy should be evaluated for CM, and renal functions should be closely monitored during treatment. There is a need for more case reports on the subject, especially in CM detected HIV-negative patients, due to the different treatment protocols and challenging clinical conditions compared to HIV-positive cases.
ISSN:1156-5233
1773-0449
DOI:10.1016/j.mycmed.2023.101388