Single intranasal administration of 17β-estradiol loaded gelatin nanoparticles confers neuroprotection in the post-ischemic brain

Globally, ischemic stroke is a leading cause of death and adult disability. Previous efforts to repair damaged brain tissue following ischemic events have been hindered by the relative isolation of the central nervous system. We have developed a gelatin nanoparticle-mediated intranasal drug delivery...

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Bibliographic Details
Published in:Nanomedicine 2020-10, Vol.29, p.102246, Article 102246
Main Authors: Joachim, Elizabeth, Barakat, Radwa, Lew, Benjamin, Kim, Kyekyoon Kevin, Ko, CheMyong, Choi, Hyungsoo
Format: Article
Language:English
Subjects:
Estrogen
Gelatin nanoparticles
Intranasal delivery
MCAO
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Summary:Globally, ischemic stroke is a leading cause of death and adult disability. Previous efforts to repair damaged brain tissue following ischemic events have been hindered by the relative isolation of the central nervous system. We have developed a gelatin nanoparticle-mediated intranasal drug delivery system as an efficient, non-invasive method for delivering 17β-estradiol (E2) specifically to the brain, enhancing neuroprotection, and limiting systemic side effects. Young adult male C57BL/6 J mice subjected to 30 min of middle cerebral artery occlusion (MCAO) were administered intranasal preparations of E2-GNPs, water soluble E2, or saline as control 1 h after reperfusion. Following intranasal administration of 500 ng E2-GNPs, brain E2 content rose by 5.24 fold (P
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2020.102246