The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats

The effects of morphine on hippocampal sensory gating (N40) during the development of morphine dependence and withdrawal were investigated in the double click auditory evoked potential (EP) suppression paradigm. Rats were made dependent upon morphine hydrochloride by a series of injections (every 12...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2005-07, Vol.382 (1), p.164-168
Main Authors: Zheng, Jiawei, Yang, Yan, Tian, Shaohua, Chen, Jin, Wilson, Fraser A.W., Ma, Yuanye
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Analgesics, Opioid - adverse effects
Animals
Auditory Perception - drug effects
Biological and medical sciences
Dependence development
Dopamine
Dopamine - metabolism
Dopamine - physiology
Dopamine Antagonists - pharmacology
Electroencephalography - drug effects
Evoked Potentials, Auditory - drug effects
Fundamental and applied biological sciences. Psychology
Haloperidol - pharmacology
Hippocampal
Hippocampus - physiopathology
Morphine
Morphine - adverse effects
Morphine Dependence - physiopathology
Rats
Rats, Sprague-Dawley
Sensory gating
Substance Withdrawal Syndrome - physiopathology
Vertebrates: nervous system and sense organs
Withdrawal
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of morphine on hippocampal sensory gating (N40) during the development of morphine dependence and withdrawal were investigated in the double click auditory evoked potential (EP) suppression paradigm. Rats were made dependent upon morphine hydrochloride by a series of injections (every 12 h) over 6 days, followed by withdrawal after stopping morphine administration. Hippocampal gating was examined during the development of dependence and withdrawal. Moreover, the DA antagonist haloperidol was used to assess the contribution of dopamine to hippocampal gating induced by morphine. Our results showed that the morphine-treated rats exhibited significantly disrupted hippocampal gating during the development of morphine dependence and this disrupted gating was partially reversed by haloperidol pretreatment. In contrast, there was significantly enhanced hippocampal gating at the fifth and sixth days of withdrawal. The dynamics of hippocampal gating during the development of morphine dependence and withdrawal suggests the interaction between the hippocampus and opioids.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.03.010