Acute repetitive transcranial magnetic stimulation reactivates dopaminergic system in lesion rats

Repetitive transcranial magnetic stimulation (rTMS) offers potential benefit as a therapeutic treatment for neurological and psychiatric disorders. However, the mechanism underlying the therapeutic effects of rTMS is still unknown. In this study, we investigated the rescue effects of rTMS in the les...

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Bibliographic Details
Published in:Neuroscience letters 2005-07, Vol.383 (1), p.77-81
Main Authors: Funamizu, Hirofumi, Ogiue-Ikeda, Mari, Mukai, Hideo, Kawato, Suguru, Ueno, Shoogo
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage
Analysis of Variance
Animals
Behavior, Animal - drug effects
Behavior, Animal - radiation effects
Biological and medical sciences
Brain - cytology
Brain - drug effects
Brain - radiation effects
Brain Diseases - chemically induced
Brain Diseases - metabolism
Brain Diseases - therapy
Cell Count
Deep Brain Stimulation
Dopamine - metabolism
Dopamine Agents - administration & dosage
Fundamental and applied biological sciences. Psychology
Immunohistochemistry - methods
Male
MPTP
Neurons - drug effects
Neurons - metabolism
Neurons - radiation effects
Neuropsychological Tests
Phosphopyruvate Hydratase - metabolism
Rats
Rats, Wistar
Rearing
rTMS
Time Factors
Transcranial Magnetic Stimulation
Tyrosine 3-Monooxygenase - metabolism
Tyrosine hydroxylase (TH)
Vertebrates: nervous system and sense organs
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Summary:Repetitive transcranial magnetic stimulation (rTMS) offers potential benefit as a therapeutic treatment for neurological and psychiatric disorders. However, the mechanism underlying the therapeutic effects of rTMS is still unknown. In this study, we investigated the rescue effects of rTMS in the lesioned rats by administering the neurotoxin MPTP (l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine). The rats received rTMS (10 trains of 25 pulses/s for 8 s) 48 h after MPTP injection, and tyrosine hydroxylase (TH) and NeuN expressions were investigated in the substantia nigra. The functional observational battery-hunched posture score for the MPTP-rTMS group was significantly lower and the number of rearing events was higher compared with the MPTP-sham group, these behavioral parameters revert to control levels. These results suggest that rTMS treatment reactivates the dopaminergic system in lesion rats.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.04.018