MPTP administration increases plasma levels of acute phase proteins in non-human primates (Macaca fascicularis)

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Parkinsonian patients and animal models of PD show inflammatory phenomena such as microglial activation and cytokine production that could modulate the progression of the...

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Bibliographic Details
Published in:Neuroscience letters 2009-09, Vol.463 (1), p.37-39
Main Authors: De Pablos, V., Barcia, C., Martínez, S., Gomez, A., Ros-Bernal, F., Zamarro-Parra, J., Soria-Torrecillas, J.J., Hernández, J., Ceron, J.J., Herrero, M.T.
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Acute-Phase Proteins - metabolism
Animals
Biological and medical sciences
C-reactive protein (CRP)
C-Reactive Protein - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine
Dopamine Agents
Fundamental and applied biological sciences. Psychology
Haptoglobin (HP)
Haptoglobins - metabolism
Inflammation - blood
Macaca fascicularis
Male
Medical sciences
Neuroinflammation
Neurology
Neuronal degeneration
Parkinson Disease, Secondary - blood
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - immunology
Parkinson's disease
Serum amyloid A (SAA)
Serum Amyloid A Protein - metabolism
Vertebrates: nervous system and sense organs
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Summary:Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Parkinsonian patients and animal models of PD show inflammatory phenomena such as microglial activation and cytokine production that could modulate the progression of the disease, since they play a crucial role in the degenerative process. Since acute phase proteins (APPs) are involved in a number of homeostatic alterations and inflammatory processes, we analyzed the levels of APPs in primates before and after treatment with MPTP. A significant increase in C-reactive protein (CRP), serum amyloid A (SAA) and haptoglobin (HP) levels after MPTP treatment. These results demonstrate that MPTP induces a systemic generalized inflammatory reaction after specific dopaminergic neurotoxicity insult, suggesting that the inflammatory process in Parkinsonism may affect other immune-inflammatory responses outside the brain.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2009.07.069