The regulation of SKF38393 on the signaling pathway of dopamine D 1 receptor in hippocampus during chronic sleep deprivation

Hippocampal functions are sensitive to sleep deficiency. Dopamine D receptor (D R) in hippocampus can regulate the expression of cAMP response element binding protein (CREB) through PKA, MAPK and phosphoinositide pathway, but which pathway plays the major role in hippocampus during Chronic sleep dep...

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Bibliographic Details
Published in:Neuroscience letters 2017-07, Vol.654, p.42-48
Main Authors: Chen, Si, Wen, Xiaosa, Liang, Han, Li, Yuxiang, Chen, Xinmin, Zhang, Dong, Shi, Rengfei, Ma, Wenling
Format: Article
Language:English
Subjects:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
Animals
Dopamine Agonists - pharmacology
Hippocampus - drug effects
Hippocampus - metabolism
Male
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - metabolism
Signal Transduction - drug effects
Signal Transduction - physiology
Sleep Deprivation - metabolism
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Summary:Hippocampal functions are sensitive to sleep deficiency. Dopamine D receptor (D R) in hippocampus can regulate the expression of cAMP response element binding protein (CREB) through PKA, MAPK and phosphoinositide pathway, but which pathway plays the major role in hippocampus during Chronic sleep deprivation (CSD) is unclear. The CSD model was created, SKF rats were administered the D R agonist (SKF38363), and hippocampus from each animal was dissected for following molecular detection. The gene and protein levels of CREB and key molecules in D R pathways were measured by real-time PCR and western blotting, respectively. Both the gene and protein expression of CREB in hippocampus decreased by CSD and improved significantly by SKF38393 (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.05.072