Manganese induces p21 expression in PC12 cells at the transcriptional level

Highlights ► Mn induces DAergic cells injury and upregulation of p21 expression in vivo . ► Mn up-regulates both mRNA and protein levels of p21 in PC12 cells. ► p21 plays a pivotal role in Mn-induced loss of cell viability and G2/M arrest. ► Mn does not stabilize the p21 protein and mRNA in PC12 cel...

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Bibliographic Details
Published in:Neuroscience 2012-07, Vol.215, p.184-195
Main Authors: Zhao, F, Zhang, J.-B, Cai, T.-J, Liu, X.-Q, Liu, M.-C, Ke, T, Chen, J.-Y, Luo, W.-J
Format: Article
Language:English
Subjects:
Age Factors
Analysis of Variance
Animals
Biological and medical sciences
Cell Cycle - drug effects
Cell Survival - drug effects
Chlorides - pharmacology
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Cyclin-Dependent Kinase Inhibitor p21 - genetics
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Male
manganese
Manganese Compounds - pharmacology
Neurology
p21
PC12 cells
PC12 Cells - drug effects
Rats
Rats, Sprague-Dawley
regulatory mechanism
RNA, Messenger - metabolism
RNA, Small Interfering - metabolism
Time Factors
Transfection
Tyrosine 3-Monooxygenase - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Mn induces DAergic cells injury and upregulation of p21 expression in vivo . ► Mn up-regulates both mRNA and protein levels of p21 in PC12 cells. ► p21 plays a pivotal role in Mn-induced loss of cell viability and G2/M arrest. ► Mn does not stabilize the p21 protein and mRNA in PC12 cells. ► The induction of p21 by Mn occurs at the transcriptional level.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.027