Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain

Highlights ► Kappa opioid agonist U50,488H alters p44/42 MAPK activity in the guinea pig. ► Males generally show greater changes induced by U50,488H than females. ► Pretreatment with norBNI antagonized the effects of U50,488H in most brain regions. ► In basolateral amygdala, U50 increased P-MAPK in...

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Bibliographic Details
Published in:Neuroscience 2012-10, Vol.223, p.447-456
Main Authors: Rasakham, K, McGillivray, K.L, Liu-Chen, L.-Y
Format: Article
Language:English
Subjects:
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology
Analgesics, Non-Narcotic - pharmacology
Animals
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Brain Mapping
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Enzymologic - drug effects
guinea pig
Guinea Pigs
kappa opioid receptor
Male
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3 - metabolism
neural activity
Neurology
p44/42 MAP kinase
Phosphorylation - drug effects
Sex Characteristics
sex difference
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Kappa opioid agonist U50,488H alters p44/42 MAPK activity in the guinea pig. ► Males generally show greater changes induced by U50,488H than females. ► Pretreatment with norBNI antagonized the effects of U50,488H in most brain regions. ► In basolateral amygdala, U50 increased P-MAPK in males but reduced it in females. ► These results highlight the need to include females in kappa opioid studies.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.07.040