Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum

• Published in: Neuroscience 2013-02, Vol.231, p.91-101
• Main Authors: Colín-González, A.L, Orozco-Ibarra, M, Chánez-Cárdenas, M.E, Rangel-López, E, Santamaría, A, Pedraza-Chaverri, J, Barrera-Oviedo, D, Maldonado, P.D
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Corpus Striatum - pathology; excitotoxicity; heme oxygenase-1; Heme Oxygenase-1 - antagonists & inhibitors; Heme Oxygenase-1 - metabolism; Male; Medical sciences; Metalloporphyrins - pharmacology; Nerve Degeneration - chemically induced; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuropharmacology; neuroprotection; Neuroprotective agent; Neuroprotective Agents - pharmacology; oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Pharmacology. Drug treatments; Protoporphyrins - pharmacology; Quinolinic Acid; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; redox modulation; Up-Regulation - drug effects; Up-Regulation - physiology
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.11.031

Highlights ► QA produces a time-course toxic pattern in the rat striatum. ► QA induces HO-1 upregulation in a time-dependent manner. ► QA-induced HO-1 upregulation matches with oxidative and cell damage. ► HO-1 inhibition by SnPP exacerbates QA-induced toxicity. ► HO-1 plays a modulatory role in the rat striatum during toxic insults.