The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes

• Published in: Neuroscience 2015-12, Vol.310, p.578-588
• Main Authors: Colín-González, A.L, Paz-Loyola, A.L, Serratos, I.N, Seminotti, B, Ribeiro, C.A.J, Leipnitz, G, Souza, D.O, Wajner, M, Santamaría, A
• Format: Article
• Language: English
• Subjects: Acids, Acyclic - metabolism; Acids, Acyclic - toxicity; Amino Acid Metabolism, Inborn Errors - metabolism; Animals; Benzoxazines - pharmacology; Brain - drug effects; Brain - metabolism; Brain Diseases, Metabolic - metabolism; Cannabinoid Receptor Agonists - pharmacology; endocannabinoid system; Glutarates - metabolism; Glutarates - toxicity; Glutaryl-CoA Dehydrogenase - deficiency; Glutaryl-CoA Dehydrogenase - metabolism; Lipid Peroxidation - drug effects; Male; Methylmalonic Acid - metabolism; Methylmalonic Acid - toxicity; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial dysfunction; Morpholines - pharmacology; Naphthalenes - pharmacology; Neurology; neuroprotection; organic acids; oxidative stress; Oxidative Stress - drug effects; Propionates - metabolism; Propionates - toxicity; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; synaptosomes; Synaptosomes - drug effects; Synaptosomes - metabolism
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.09.043

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