A scalable computer-aided detection system for microcalcification cluster identification in a pan-European distributed database of mammograms

• Published in: Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Accelerators, spectrometers, detectors and associated equipment, 2006-12, Vol.569 (2), p.601-605
• Main Authors: Retico, A., Delogu, P., Fantacci, M.E., Preite Martinez, A., Stefanini, A., Tata, A.
• Format: Article
• Language: English
• Subjects: Computer-aided detection; GRID applications; Mammography; Neural networks; Wavelets
• ISSN: 0168-9002; 1872-9576
• DOI: 10.1016/j.nima.2006.08.094

A computer-aided detection (CADe) system for microcalcification cluster identification in mammograms has been developed in the framework of the EU-founded MammoGrid project. The CADe software is mainly based on wavelet transforms and artificial neural networks. It is able to identify microcalcifications in different kinds of mammograms (i.e. acquired with different machines and settings, digitized with different pitch and bit depth or direct digital ones). The CADe can be remotely run from GRID-connected acquisition and annotation stations, supporting clinicians from geographically distant locations in the interpretation of mammographic data. We report the FROC analyses of the CADe system performances on three different dataset of mammograms, i.e. images of the CALMA INFN-founded database collected in the Italian National screening program, the MIAS database and the so-far collected MammoGrid images. The sensitivity values of 88% at a rate of 2.15 false positive findings per image (FP/im), 88% with 2.18 FP/im and 87% with 5.7 FP/im have been obtained on the CALMA, MIAS and MammoGrid database, respectively.