Distribution of lead in the brain tissues from DNTC patients using synchrotron radiation microbeams

Diffuse neurofibrillary tangles with calcification (DNTC) is a form of dementia with certain characteristics. Its pathology is characterized by cerebrum atrophy, calcification on globus pallidus and dentate nucleus and diffuse neurofibrillary tangles without senile plaques. In the present study brai...

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Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2005-12, Vol.241 (1-4), p.681-684
Main Authors: Ide-Ektessabi, Ari, Ota, Yukihide, Ishihara, Ryoko, Mizuno, Yutaka, Takeuchi, Tohru
Format: Article
Language:English
Subjects:
Biological techniques and instrumentation
Biomedical engineering
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Summary:Diffuse neurofibrillary tangles with calcification (DNTC) is a form of dementia with certain characteristics. Its pathology is characterized by cerebrum atrophy, calcification on globus pallidus and dentate nucleus and diffuse neurofibrillary tangles without senile plaques. In the present study brain tissues were prepared from patients with patients DNTC, calcified and non-calcified Alzheimer’s disease (AD) patients. The brain tissues were examined non-destructively by X-ray fluorescence (XRF) spectroscopy using synchrotron radiation (SR) microbeams for trace metallic elements Ca, Fe, Cu, Zn and Pb. The XRF analysis showed that there were Pb concentrations in the calcified areas in the brain tissues with both DNTC and AD but there was none in those with non-calcified AD.
ISSN:0168-583X
1872-9584
DOI:10.1016/j.nimb.2005.07.164