P25 Hydrogen sulfide attenuates angiotensin II-induced hypertension, proteinuria and renal damage

Hypertension and proteinuria are important mediators of renal damage. Since H2S has vasodilatory, anti-inflammatory and antioxidant properties, we investigated its effects in Angiotensin II (Ang II)-induced hypertensive renal disease in rats. Treatment with H2S donors (NaHS or sodium thiosulfate (ST...

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Published in:Nitric oxide 2014-05, Vol.39, p.S23-S24
Main Authors: Frenay, Anne-Roos S., Snijder, Pauline M., Koning, Anne M., Bachtler, Matthias, Pasch, Andreas, Kwakernaak, Arjan J., van den Berg, Else, Bos, Eelke M., Hillebrands, Jan-Luuk, Navis, Gerjan, Leuvenink, Henri G.D., van Goor, Harry
Format: Article
Language:English
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Summary:Hypertension and proteinuria are important mediators of renal damage. Since H2S has vasodilatory, anti-inflammatory and antioxidant properties, we investigated its effects in Angiotensin II (Ang II)-induced hypertensive renal disease in rats. Treatment with H2S donors (NaHS or sodium thiosulfate (STS)) during three weeks of Ang II infusion reduced hypertension by 22% and 18% resp (p
ISSN:1089-8603
1089-8611
DOI:10.1016/j.niox.2014.03.075