P108 Hydrogen sulfide releaser with xanthone-type photocages

• Published in: Nitric oxide 2014-05, Vol.39, p.S48-S48
• Main Authors: Nakagawa, Hidehiko, Fukushima, Naoki, Ieda, Naoya, Miyata, Naoki
• Format: Article
• Language: English
• ISSN: 1089-8603; 1089-8611
• DOI: 10.1016/j.niox.2014.03.158

Hydrogen sulfide (H2S) has been recognized as one of the important gaseous cellular signaling molecules. H2S is considered to be involved in vascular relaxation, neurotransmission, and inflammation. To investigate the physiological and pharmacological actions of H2S, the compounds releasing H2S in situ are very useful due to its toxicity and instability. Although inorganic sulfide salts such as NaSH have been commonly used as H2S releasing chemicals, several H2S releasing organic compounds were reported so far. We are also interesting in H2S releasing organic molecules, and previously developed a photocontrollable H2S releaser based on the photochemical reaction of ketoprofen-derived photocage (photolabile protecting group). The ketoprofen-type photocage showed good reactivity in biological fluid. We further envisaged development of photocontrollable H2S releasers with other photocages, especially absorbing longer wavelength light, and in this study, we designed and synthesized a new photocontrollable H2S releaser with xanthone-type photocages, which can release H2S by light irradiation in the 330–380nm range. The compound could release H2S more efficiently than our previous one, and was applicable to cultured cells.