Resting myocardial wall motion, end systolic and end diastolic volume, and mass with cardiac PET correlates with myocardial blood flow changes during hyperemia

• Published in: Journal of nuclear cardiology 2004-07, Vol.11 (4), p.S30-S30
• Main Authors: Hickey, K.T, Giedd, K.N, Sciacca, R.R, Rodriguez, O, Chou, R.L, Bergmann, S.R, Bokhari, S
• Format: Article
• Language: English
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1016/j.nuclcard.2004.06.127

Objective: The aim of this study was to examine the relationship between regional wall motion (WM), LV ejection fraction (EF), end systolic volume (ESV), end diastolic volume (EDV) and mass (M) obtained with gated 13NH 3at rest with changes in myocardial blood flow (MBF) during hyperemia. Methods: 40 patients (59 + 11 years; 32 males) undergoing PET imaging to measure MBF at rest and during adenosine were studied. Patients received an i.v. injection of 13NH 3at rest and again three minutes into a 6 minute adenosine infusion. The first 2 minutes of data were collected dynamically to measure MBF in ml/g/min. Then, a single 13-minute scan was acquired in the gated mode to obtain WM, EF, ESV, EDV, and M. Results: Measures of LV function did not correlate with global MBF but did correlate with global hyperemic MBF (EDV [r=-0.44, p=0.01], ESV [r=-0.43, p=0.02], and M [r=-0.48, p=0.01]) as well as the change in MBF from rest to hyperemia (EDV [r=-0.44, p=0.01], ESV [r=-0.41, p=0.02], and M [r=-0.38, p=0.04]). Regional MBF during hyperemia averaged 1.97 + 0.62 ml/g/min in normal WM segments and was decreased to 1.42 + 0.46 ml/g/min in hypokinetic segments and 0.98 + 0.41 ml/g/min in akinetic/dyskinetic segments (p < 0.01 for each comparision). Conclusion: The data demonstrate that gated PET measures of WM and LV function obtained at rest during routine 13NH 3imaging are clinically useful and predict the presence of diminished regional MBF during hyperemia. Thus, gating of 13NH 3 studies provides independent information, helps distinguish artifacts from true perfusion defects, and can be readily integrated into routine perfusion imaging with PET.