Predictive Value of Nutritional Scores in Non-Valvular Atrial Fibrillation Patients: Insights From the AFTER-2 Study

Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems. A total of 2592 patie...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-11, p.103794, Article 103794
Main Authors: Söner, Serdar, Güzel, Tuncay, Aktan, Adem, Kılıç, Raif, Arslan, Bayram, Demir, Muhammed, Güzel, Hamdullah, Taştan, Ercan, Okşul, Metin, Cömert, Adnan Duha, Ertaş, Faruk
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Atrial fibrillation
controlling nutritional status
geriatric nutritional risk index
malnutrition
prognostic nutritional index
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creator Söner, Serdar
Güzel, Tuncay
Aktan, Adem
Kılıç, Raif
Arslan, Bayram
Demir, Muhammed
Güzel, Hamdullah
Taştan, Ercan
Okşul, Metin
Cömert, Adnan Duha
Ertaş, Faruk
description Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems. A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study. All participants were divided into two groups: 761 patients who died and 1831 patients who were alive. The malnutrition status of all participants was evaluated with three scoring systems. The primary outcome was all-cause mortality. The mean age of the population was 68.7 ± 11.1 years, and 55.5% were female. According to Cox regression analysis, the geriatric nutritional risk index (GNRI) (HR=0.989, 95% CI: 0.982-0.997, p=0.007), controlling nutritional status (CONUT) score (HR=1.121, 95% CI: 1.060-1.185, p
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We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems. A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study. All participants were divided into two groups: 761 patients who died and 1831 patients who were alive. The malnutrition status of all participants was evaluated with three scoring systems. The primary outcome was all-cause mortality. The mean age of the population was 68.7 ± 11.1 years, and 55.5% were female. According to Cox regression analysis, the geriatric nutritional risk index (GNRI) (HR=0.989, 95% CI: 0.982-0.997, p=0.007), controlling nutritional status (CONUT) score (HR=1.121, 95% CI: 1.060-1.185, p&lt;0.001), and prognostic nutritional index (PNI) (HR=0.980, 95% CI: 0.962-0.999, p=0.036) were found to be significant mortality predictors. ROC curve analysis indicated GNRI (AUC=0.568), CONUT (AUC=0.572), and PNI (AUC=0.547) had moderate predictive values. Kaplan-Meier analysis showed that increasing the risk class based on GNRI (p&lt;0.001) and CONUT (p&lt;0.001) was associated with decreased survival, while PNI staging had no statistically significant effect (p=0.266). Malnutrition, determined by three scoring systems, was found to be an independent predictor of all-cause mortality in NVAF patients. Nutritional examination may provide useful information for prognosis and risk stratification in patients with NVAF. •AF is a common arrhythmia and is associated with high morbidity and mortality.•The study examines the effect of malnutrition on AF patients.•Malnutrition prevalence was 35.7% in GNRI, 36.9% in CONUT, and 15.1% in PNI.•Malnutrition is an independent predictor of all-cause mortality.•GNRI and CONUT scores were the most effective predictors.</description><identifier>ISSN: 0939-4753</identifier><identifier>ISSN: 1590-3729</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2024.103794</identifier><identifier>PMID: 39757075</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Atrial fibrillation ; controlling nutritional status ; geriatric nutritional risk index ; malnutrition ; prognostic nutritional index</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2024-11, p.103794, Article 103794</ispartof><rights>2024</rights><rights>Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. 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subjects Atrial fibrillation
controlling nutritional status
geriatric nutritional risk index
malnutrition
prognostic nutritional index
title Predictive Value of Nutritional Scores in Non-Valvular Atrial Fibrillation Patients: Insights From the AFTER-2 Study
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