Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-12, p.103837, Article 103837
• Main Authors: Rubín-García, María, Vitelli-Storelli, Facundo, Álvarez-Álvarez, Laura, Fitó, Montserrat, Vázquez-Ruiz, Zenaida, Salas-Salvadó, Jordi, Corella, Dolores, Serra-Majem, Lluis, Warnberg, Julia, Romaguera, Dora, Estruch, Ramón, Pintó, Xavier, Martínez, J Alfredo, Vázquez, Clotilde, Vidal, Josep, Tur, Josep A., Alonso-Gómez, Ángel M., Ros, Emilio, Vioque, Jesús, López-Miranda, José, Bueno-Cavanillas, Aurora, Tinahones, Francisco J., Lapetra, José, Daimiel, Lidia, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Babio, Nancy, Schröder, Helmut, Lamuela-Raventós, Rosa M., Martín-Sánchez, Vicente, Zamora-Ros, Raúl
• Format: Article
• Language: English
• Subjects: (Poly)phenols; body weight; inflammation; physical activity
• ISSN: 0939-4753
• DOI: 10.1016/j.numecd.2024.103837

To prospectively evaluate the associations between changes in (poly)phenol intake, body weight(BW), and physical activity(PA) with changes in an inflammatory score after 1-year. This is a prospective observational analysis involving 484 participants from the PREDIMED-Plus with available inflammatory measurements. (Poly)phenol intake was estimated using a validated semi-quantitative food frequency questionnaire and the Phenol-Explorer database. An inflammatory score was calculated based on 8 blood biomarkers (IL-6, IL-8, IL-18, MCP-1, C-peptide, hs-CRP, leptin, and RANTES). The association between BW, PA, (poly)phenol intake and inflammatory score was evaluated using structural equations. Mediation analyses were performed to assess the relationship between change in (poly)phenol intake and inflammatory score was mediated by the change in BW. A higher increase in total (poly)phenol intake was related to a decrease in the inflammatory score (β=-0.005mg/1000Kcal;CI95% =-0.100,0.000) along with a decrease in BW (β=-0.006mg/1000Kcal;CI95%=-0.010,-0.003). Increased PA was associated with a lower inflammatory score (β=-0.129MET-min/d;CI95% = -0.238,-0.021) and BW (β=-0.248MET-min/d; CI95%=-0.343,-0.152). Finally, a decrease in BW was associated with a decrease in the inflammatory score (β=0.240kg;CI95%=0.155,0.325). Mediation analyses revealed that changes in BW explained 22% of the overall association between changes in (poly)phenol intake and inflammatory score. An inverse association between changes in (poly)phenol intake and inflammatory status was observed, with BW playing a significant mediating role, emphasising the impact of BW reduction on inflammation reduction. •(Poly)phenol intake, body weight and physical activity were related with inflammation score•A higher increase in total (poly)phenol intake was related to a decrease in the inflammatory score•Changes in total (poly)phenol intake was also related to a decrease in body weight•More physical activity and less body weight were associated with less inflammation