Significant increase of serum B12 levels with high-dose oral vitamin B12 supplementation with or without intrinsic factor after Roux-en-Y gastric bypass: A randomized controlled trial

VitB12 deficiency is frequently encountered after RYGB. Low-dose oral supplements are not sufficient to avoid this deficiency, often implying treatment with intramuscular injections. As IF plays an important role in vitB12 absorption, there might be an additional effect in adding IF to oral vitB12 s...

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Bibliographic Details
Published in:Obesity medicine 2022-06, Vol.32, p.100416, Article 100416
Main Authors: Ooms, Melissa, Vanheule, Greet, Van Langenhove, Karen, De Wever, Nick, Vynckier, An-Katrien, Van Den Driessche, Mieke, Van Cauwenberge, Sebastiaan, Dillemans, Bruno
Format: Article
Language:English
Subjects:
Intrinsic factor
Oral supplementation
Roux-en-Y gastric Bypass
Vitamin B12
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Summary:VitB12 deficiency is frequently encountered after RYGB. Low-dose oral supplements are not sufficient to avoid this deficiency, often implying treatment with intramuscular injections. As IF plays an important role in vitB12 absorption, there might be an additional effect in adding IF to oral vitB12 supplements. This randomized, monocentric, double-blind, placebo-controlled trial evaluates the short-term effect of high-dose (1000 μg) oral vitB12 supplementation on serum vitB12 levels after RYGB. 225 patients were randomized into three treatment arms: vitB12, vitB12 in combination with intrinsic factor (vitB12IF) or placebo. Serum vitB12 levels 6 months postoperatively were significantly higher in patients receiving vitB12 compared to placebo (p 
ISSN:2451-8476
2451-8476
DOI:10.1016/j.obmed.2022.100416