Ginger extract ameliorates endocrine-metabolic disturbances in letrozole-induced PCOS mice model by altering androgen-adiponectin status

• Published in: Obesity medicine 2023-05, Vol.39, p.100485, Article 100485
• Main Authors: Shah, Mohd Zahoor ul haq, Shrivastava, Vinoy Kumar, Mir, Manzoor Ahmad
• Format: Article
• Language: English
• Subjects: Adiponectin; Ginger; Insulin resistance; Oxidative stress; Polycystic ovary syndrome
• ISSN: 2451-8476; 2451-8476
• DOI: 10.1016/j.obmed.2023.100485

Polycystic ovarian syndrome (PCOS) has an impact on numerous women's health issues worldwide. Since the specific aetiology is unknown, the diagnostic criteria are currently insufficient, which contributes to the under diagnosis and under treatment of PCOS in many women. Eighteen mature Parkes strain mice (4–5 weeks old) weighing 18–21 g were at random separated to three groups with six mice each: Group I served as the control; Group II was given Letrozole (LET) dissolved in normal saline water (0.9%) orally by using oral gavage at the dose of (6 mg/kg bw) for twenty one days to induce PCOS followed by 60 days without treatment; Group III was given LET (6 mg/kg) for the twenty one days, followed by the oral gavage treatment of ginger (350 mg/kg bw orally daily) for 60 days. In our study we observed that mice with PCOS had increased body weight, ovary mass, blood glucose, insulin, Homa insulin resistance (IR), cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) as well as increase in testosterone, and luteinizing hormone (LH). We observed decline in estrogen, follicle stimulating hormone (FSH) and decreased antioxidant capacity in the ovary. These alterations were linked to decreased adiponectin in mice. However after ginger administration these changes were reversed. The findings from our research suggested that adiponectin has direct impact on metabolic and endocrine facets of PCOS, & its drop can cause women infertility. Therefore, boosting the circulation of adiponectin may be employed as a remedy to metabolic, and perhaps endocrine, conditions in polycystic ovarian syndrome-affected individuals. [Display omitted] •Polycystic ovarian syndrome (PCOS) has an impact on numerous women's health issues worldwide.•Adiponectin has direct impact on endocrine and metabolic aspects in PCOS.•Ginger increases the concentration of adiponectin in letrozole induced PCOS.•Ginger extract improves insulin resistance in letrozole induced PCOS.•Ginger extract mitigates endocrine-metabolic disorders in letrozole induced PCOS.