CLEAR CELL AMELOBLASTIC CARCINOMA. A CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2019-07, Vol.128 (1), p.e34-e34
• Main Authors: GarcÍa-Ramos, Ms. Celina, Tapia, Dr. Roberto Onner Cruz, Portilla-Robertson, Dr. Javier
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.02.056

To report a case of ameloblastic carcinoma with onset in the lower jaw, showing histological traits as well as immunological profile with molecular markers expression and tumor proliferation. Ameloblastic carcinoma (AC) is a malignant epithelial odontogenic tumor combining ameloblastoma's histological features with malignant cytological traits. We hereby present the case report of a 62 year old female who was referred to the Oral Medicine Clinic, Faculty of Dentistry, National Autonomous University of Mexico (UNAM): The patient exhibited a swollen area in the anterior section of the lower jaw with destruction of cortical bone and displacement of anterior teeth; lesion was a nodular and ulcerated mass. Radiographic imaging revealed a poorly circumscribed radiolucent lesion in the anterior section of the mandible. Histological examination of a biopsy specimen revealed a lesion with proliferation of polygonal and cylindrical cells arranged in an hypercellular solid mass, with presence of abundant mitotic figures as well as some areas with necrosis. Some hyalinization areas in connective tissue were found along with islands of abundant glycogen-rich cells, positive to PAS. Neoplastic cells were nuclear for beta-catenin amelogenin and 40% for ki67 AC is an aggressive, malignant neoplasm with onset in the jaws, it can arise de novo or be secondary to the malignant transformation of a pre-existing ameloblastoma. Presence of clear cells is extremely rare; immunohistochemical analysis confirmed presence of glycogen. Metaplasia of clear cells n this tumor has not been reported as prognostic factor, nevertheless, it is and indicator of the lesion's morphological diversity. Reports of ameloblastic carcinoma with clear cells are rare, nevertheless, long-term follow-up of ameloblastoma is of the utmost importance bearing in mind that these are aggressive tumors with high recurrence to malignify.