OZONOTHERAPY IN JAW OSTEONECROSIS RELATED TO RADIOTHERAPY AND BISPHOSPHONATE: A CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-01, Vol.129 (1), p.e26-e26
• Main Authors: DE LIMA DANTAS, JULIANA BORGES, CARRERA, MANOELA, MARCHIONNI, ANTÔNIO MÁRCIO TEIXEIRA, DE PAULA RIBEIRO BORGES, DANILO, DE ALMEIDA REIS, SILVIA REGINA, GUIMARÃES, LAÍS BASTOS, MEDRADO, ALENA PEIXOTO
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.055

Several antineoplastic treatments disturb wound repair and may even contribute to bone necrosis development. The present study aims to report a case of osteoradionecrosis in the mandible, and how its sequels were controlled by ozonotherapy. A 73-year-old female patient with a history of infiltrative ductal breast carcinoma with mandibular metastasis underwent chemotherapy and radiotherapy in head and neck region. Three years later, she was diagnosed with right hemimandibular osteoradionecrosis that exhibited communication with buccal cavity presenting as a chronic, suppurative, and persistent infection. Adjuvant therapy with ozone was applied through the cutaneous fistula and the exposed necrotic bone. Additionally, nonvital bone debridement was performed. The patient is nonsymptomatic after 1-year follow-up. It is proposed that ozone therapy, due to its antibacterial and immunoregulatory mechanism of action, was an important therapeutic agent for improving the patient's quality of life.