THERAPY FOR ODONTOGENIC LESIONS WITH 5-FLUOROURACIL TOPICAL: A CASE REPORT

Five-fluorouracil (5-FU) is an antimetabolite drug used in the treatment of various cancers, including basal cell carcinomas (BCC). Some authors believe that odontogenic keratocyst (OKC) would respond to 5-FU treatment because of their similarities to BCCs in molecular etiopathogenesis. A case of an...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-01, Vol.129 (1), p.e94-e94
Main Authors: DE OLIVEIRA PINTO CALDAS, RAPHAELLA, DA SILVA BARRETO, JADE DIONÍSIO, DOS SANTOS, CÉSAR WERNECK NOCE, MICELI, ANA LUCIA CARPI, DE ALMEIDA FREIRE, NATHÁLIA, ABRAHÃO, ALINE CORRÊA, DA ROCHA MIRANDA VENTURI, BEATRIZ
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Language:English
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Summary:Five-fluorouracil (5-FU) is an antimetabolite drug used in the treatment of various cancers, including basal cell carcinomas (BCC). Some authors believe that odontogenic keratocyst (OKC) would respond to 5-FU treatment because of their similarities to BCCs in molecular etiopathogenesis. A case of an OKC treated with 5-FU is presented in this study. A 47-year-old man sought service to extract #17. The panoramic radiograph revealed a unilocular radiolucent lesion in the body and ascending mandibular ramus. The extraction of #17 and incisional biopsy were performed, and the histopathologic diagnosis established was odontogenic keratocyst. Therefore, it was decided to perform a marsupialization and intralesional 5-FU. As a result, exuberant bone neoformation was observed, mainly in the basilar region of the mandible. Follow-up examination 4 months later showed no evidence of recurrence, and the patient will be followed up so we can decide if another surgical procedure is necessary.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2019.06.394