CURCUMA LONGA L. HAS THERAPEUTIC EFFECT IN CHEMOTHERAPY-INDUCED ORAL MUCOSITIS IN HAMSTERS DECREASING ANGIOGENESIS AND TRANSFORMING GROWTH FACTOR-β1

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-01, Vol.129 (1), p.e135-e135
• Main Authors: SCHMIDT, TUANY RAFAELI, CURRA, MARINA, BATISTA, ALINE CARVALHO, ANDRADES, MICHAEL, VALADARES, MARIZE, MARRETO, RICARDO NEVES, MARTINS, MANOELA DOMINGUES
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.588

We explored the effects of mucoadhesive formulation with Curcuma longa L. extract (MCL) on oral mucositis induced by 5-fluorouracil in hamsters. Seventy-two golden Syrian hamsters separated into 4 groups: control group, placebo group (no active substance), positive control group (AdMuc topical chamomile), and MCL group (topical use of mucoadhesive Curcuma longa). The animals received an intraperitoneal injection of 5-fluorouracil on days 0 and 2. On days 3 and 4, the buccal mucosa was scratched, and therapy was initiated on day 5. The animals received 2 daily applications of the product according to the experimental group. Wound area was calculated and histologic sections of 3 μm were stained by hematoxylin and eosin for semiquantitative analysis of re-epithelization and degree of tissue inflammation. Immunohistochemistry was used for transforming growth factor β1 (TGF-β1) and CD31 analysis. The MCL group showed a greater clinical reduction of the mucositis lesions at day 8, a higher degree of re-epithelization, and a lower inflammatory process, with a lower angiogenesis and TGF-β1 epithelial labeling compared with the placebo and control groups (P < .05). MCL and chamomile were similar. MCL Curcuma longa L. has a therapeutic effect accelerating the healing of oral mucositis reducing the inflammatory response and increasing re-epithelization.