DETERMINATION AND DIAGNOSTIC VALUE OF CA9-RNAM IN PERIPHERAL BLOOD OF PATIENTS WITH ORAL LEUKOPLAKIA

The present work deals with the determination of CA9 in oral leukoplakia as the highest oral malignant disorder in blood and tissues. RT-qPCR was performed on 47 blood samples (21 patients with leukoplakia, 2 with oral squamous cell carcinoma [OSCC] and 24 healthy patients) and on 11 tissue samples...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-01, Vol.129 (1), p.e161-e161
Main Authors: VILA, PILAR GANDARA, LÓPEZ, MANUEL TORRES, PETRONACCI, CINTIA CHAMORRO, IRUEGAS, ELENA PADÍN, CARRIÓN, ANDRÉS BLANCO, GARCÍA, ABEL, SAYÁNS, MARIO PÉREZ
Format: Article
Language:English
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Summary:The present work deals with the determination of CA9 in oral leukoplakia as the highest oral malignant disorder in blood and tissues. RT-qPCR was performed on 47 blood samples (21 patients with leukoplakia, 2 with oral squamous cell carcinoma [OSCC] and 24 healthy patients) and on 11 tissue samples (3 leukoplakia, 4 OSCC, and 4 samples of healthy tissue). There are significant differences in expression between the different groups (F = 4.057, P = .006). The Duncan post hoc test shows that the only group that differentiates is the tumor tissue. Using the Wilcoxon test, different covariables of patients with leukoplakia were analyzed with respect to the group of healthy patients and no significant differences were observed. The diagnostic route through liquid biopsy has not been conclusive in this study, but there are significant differences in the levels analyzed in the different tissue samples.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2019.06.688