CICATRICIAL EFFECT OF LIBIDIBIA FERREA ORABASE OINTMENT ON ULCERS IN THE ORAL CAVITY OF RATS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-09, Vol.130 (3), p.e281-e282
• Main Authors: MELO, LUCIANA ALEIXO DOS SANTOS DE, BANDEIRA, MARIA FULGêNCIA COSTA LIMA, SANTOS, LILIANE LISBOA DA COSTA, ALVES, ANA PAULA NEGREIROS NUNES, JUNIOR, ANTôNIO ERNANDO CARLOS FERREIRA, TODA, CARINA, CONDE, NIKEILA CHACON OLIVEIRA
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.778

Objective: To evaluate the cicatricial effect of Libidibia ferrea 2% orabase ointment on ulcerative lesions induced in the oral cavity of rats. Study design: An experimental study, in vivo, with the induction of ulcerative lesions in the oral cavity of rats. The animals were divided into 4 groups: negative control (G1: no treatment), positive control (G2: triamcinolone acetonate ointment), control orabase (G3: orabase), and the test group (G4: L. ferrea 2% orabase ointment) and evaluated through clinical and histopathological parameters after ulcerative induction. Results: Regarding the diameter of ulcers, the G2 group showed no significant difference among the times tested (P>0.05). As for G3, there was a significant reduction of ulcers among the times tested (P< .05). The ulcers presented a histologic pattern with scores 4 and 3 at days 1 and 5, respectively. At day 10, significant differences were observed among groups (P = .002). Regarding the weight of the animals, in G4, the weight gain during the experiment was higher than in the other groups and times. Conclusion: Based on the results, it is possible to conclude that L. ferrea ointment has cicatricial potential for the healing of ulcers induced in rats.