Probable etoricoxib-induced fixed drug eruption involving the oral mucosa: A case report

Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by recurrence of lesions at the same sites each time a specific drug is taken. Oral mucosal involvement is rare. Nonsteroidal anti-inflammatory drugs are one of the most common offending drug groups in FDE; however, selecti...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2021-04, Vol.131 (4), p.e100-e107
Main Authors: Perks, Alexandra, Bates, Timothy John, Velangi, Shireen, Brown, Rachel M., Poveda-Gallego, Ana
Format: Article
Language:English
Subjects:
Drug Eruptions - diagnosis
Drug Eruptions - etiology
Etoricoxib
Humans
Mouth Mucosa
Patch Tests
Skin
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Summary:Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by recurrence of lesions at the same sites each time a specific drug is taken. Oral mucosal involvement is rare. Nonsteroidal anti-inflammatory drugs are one of the most common offending drug groups in FDE; however, selective cyclooxygenase-2 inhibitors, such as etoricoxib, are rarely implicated. We present a case of oral mucosal and cutaneous FDE induced by etoricoxib that, to the best of our knowledge, is the first reported case of this nature. We describe the diagnostic challenges and review the pertinent literature. The value of drug provocation testing and patch testing in FDE is also discussed.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2020.12.019