MOLECULAR PROFILING OF TEAR FLUIDS REVEALS SIGNATURES OF MALIGNANT TRANSFORMATION INTO ORAL CANCER

We aimed to find biological signatures of malignant transformation using non-invasive liquid biopsy. Unstimulated tears from patients with OL (N=10), PVL (N=10), OSCC (n=14), and control patients (N=10) were collected, and submitted to discovery-based proteomics by liquid chromatography-tandem mass...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2023-07, Vol.136 (1), p.e31-e31
Main Authors: SANTOS, ERISON SANTANA DOS, GRANATO, DANIELA CAMPOS, CARNIELLI, CAROLINA MORETTO, SILVA, ANA CAROLINA PRADO-RIBEIRO E, SANTOS-SILVA, ALAN ROGER, LOPES, MARCIO AJUDARTE, LEME, ADRIANA FRANCO PAES
Format: Article
Language:English
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Summary:We aimed to find biological signatures of malignant transformation using non-invasive liquid biopsy. Unstimulated tears from patients with OL (N=10), PVL (N=10), OSCC (n=14), and control patients (N=10) were collected, and submitted to discovery-based proteomics by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The data were analyzed by the software MaxQuant (proteomics), Byonics (N-glycoproteomics), and PEAKS database (post-translational modifications). Differential abundance between the groups was assessed by ANOVA following the Tukey test (p0.5; p
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2023.03.065