PLASMACYTOMA AND PLASMA CELL MYELOMA AFFECTING THE JAWS: A MULTI-INSTITUTIONAL COLLABORATIVE STUDY

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2023-07, Vol.136 (1), p.e38-e38
• Main Authors: de SOUZA, Lucas Lacerda, VARGAS, Pablo Agustin, ANDRADE, Bruno Augusto Benevenuto DE, PIRES, Fabio Ramôa, SOARES, Ciro Dantas, PONTES, Hélder Antônio Rebelo, ALMEIDA, Oslei Paes DE
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.03.093

Plasma cell neoplasms represent the proliferation of single clones of plasma cells with monoclonal immunoglobulin production. This study aimed to report a case series of plasmacytoma (PMC) and multiple myeloma (MM) of the oral cavity. Data were retrospectively retrieved and clinical, radiographic, microscopic, immunohistochemistry, and follow-up status were collected. Fifty-two cases were included (28 PMC and 24 MM), with a mean age of 59.4 years (range 27-88) and no sex predilection. Lesions were mostly presented as painful swellings in the mandible. Radiographic aspects showed poorly defined multilocular lesions, while microscopic examinations showed a proliferation of plasma cells with abundant eosinophilic cytoplasm. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, with a predominance of kappa light chain monoclonality. Overall survival was poor, and after 5 years, 26.6% of the patients were still alive. PMC and MM are aggressive neoplasms with a poor prognosis for affected patients.