ORAL VERRUCIFORM XANTHOMA: REPORT OF TWO CASES

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2023-07, Vol.136 (1), p.e42-e42
• Main Authors: BATTISTELLI, Luisa Souza, AMÉRICO, Marcia Gimenes, GONÇALVES, Ana Beatriz Simeão, ANBINDER, Ana Lia
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.03.113

Oral verruciform xanthoma (VX) is a benign lesion of unknown etiology, usually found in the gingiva and palate. This study reports on two cases of this uncommon lesion. The first is a nodule in the upper gingiva of an adult man, with the clinical diagnosis of squamous papilloma. The second is a white plaque on the tongue of a 64-year-old man, clinically diagnosed as leukoplakia or reactive hyperkeratosis. After excisional biopsy, both lesions presented a proliferation of squamous epithelium, with elongated rete ridges and numerous foamy macrophages (CD68+) within the connective tissue papillae, classified respectively as flat and verrucous. The first patient died during follow up, but the second showed no signs of recurrence one year after the biopsy. In a 60-year period, we have only 4 cases of VX (0.025%), a lesion that could be clinically misguided as other papillary or verrucous lesions.