IMMUNOEXPRESSION OF STEM CELL MARKERS IN AMELOBLASTOMA

Ameloblastoma (AME) is a benign, odontogenic neoplasm characterized by a locally invasive growth pattern. In the interest of understanding the aggressiveness of neoplasms, research on the role of stem cells has gained prominence. SOX-2, NANOG, and OCT4 transcription factors are important stem cell b...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2023-07, Vol.136 (1), p.e68-e69
Main Authors: BALBINOT, Karolyny Martins, de MENDONÇA, Raíssa Pinheiro, DIAS, Aline Marques, RAMOS, Rommel Thiago Jucá, KATAOKA, Maria Sueli da Silva, JÚNIOR, Sérgio de Melo ALVES, PINHEIRO, João de Jesus Viana
Format: Article
Language:English
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Summary:Ameloblastoma (AME) is a benign, odontogenic neoplasm characterized by a locally invasive growth pattern. In the interest of understanding the aggressiveness of neoplasms, research on the role of stem cells has gained prominence. SOX-2, NANOG, and OCT4 transcription factors are important stem cell biomarkers. Immunohistochemistry was performed to verify the expression of these transcription factors in tissue samples of AME, dentigerous cyst (CD), and dental follicle (DF). In addition, indirect immunofluorescence and transcriptomic analysis were performed from a cell line derived from AME (AME-hTERT). The expression of SOX-2, NANOG, and OCT4 was observed in tissue samples and in the AME-hTERT cell line. Higher immunostaining of the studied proteins was observed in AME in comparison to CD and FD (p
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2023.03.238