RADIATION-INDUCED CHANGES IN ORAL MUCOSA TISSUES- REPORT OF SEVEN CASES

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2024-06, Vol.137 (6), p.e262-e262
• Main Authors: KIMURA, Talita de Carvalho, LAVAREZE, Luccas, TINCANI, Alfio José, CHONE, Carlos Takahiro, EGAL, Erika Said Abu, ALTEMANI, Albina, MARIANO, Fernanda Viviane
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.12.550

High doses of radiation therapy (RT) can lead to adverse reactions in adjacent tissues. However, descriptions of oral mucosa alterations following RT are limited, and it is crucial to avoid overdiagnosis. In this report, we present seven cases demonstrating morphological changes in the oral mucosa post-RT. Of the seven patients, six were treated for oral squamous cell carcinoma, and one for humerus fibromyxosarcoma. All patients received radiation therapy in the head and neck region. The cases exhibited mild epithelial changes alongside focal cellular atypia in fibroblasts and endothelial cells. Additionally, stromal fibrosis was observed, accompanied by a chronic inflammatory infiltrate. During follow-up, three patients were disease-free, one succumbed to metastatic disease, and three were lost to follow-up. In summary, the main findings in these cases were stromal cell atypia and fibrosis. Clinical history and morphological findings play a crucial role in confirming the absence of malignant cells. This research was supported by CAPES.