Optical trapping of red blood cells and two-photon excitation-based photodynamic study using a femtosecond laser

We have implemented an optical manipulation system based on femtosecond laser tweezers for biological research. Stable optical trapping of human red blood cells was observed. We measured the optical trapping capability of the femtosecond laser tweezers in comparison with continuous-wave laser tweeze...

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Bibliographic Details
Published in:Optics communications 2005-12, Vol.256 (4-6), p.358-363
Main Authors: Mao, Fang-lin, Xing, Qi-rong, Wang, Kai, Lang, Li-ying, Wang, Zhuan, Chai, Lu, Wang, Qing-yue
Format: Article
Language:English
Subjects:
Atomic and molecular physics
Biological and medical sciences
Biology
Exact sciences and technology
Femtosecond pulse
Fundamental and applied biological sciences. Psychology
Fundamental areas of phenomenology (including applications)
General aspects
Instrumentation. Materials. Reagents. Research laboratory organization
Molecular properties and interactions with photons
Nonlinear optics
Optical cooling of molecules
trapping
Optical manipulation
Optics
Photon interactions with molecules
Physics
Two-photon phototherapy dynamics
Ultrafast processes
optical pulse generation and pulse compression
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Summary:We have implemented an optical manipulation system based on femtosecond laser tweezers for biological research. Stable optical trapping of human red blood cells was observed. We measured the optical trapping capability of the femtosecond laser tweezers in comparison with continuous-wave laser tweezers. Photodynamic therapy based on two-photon excitation at single cell level was also performed on our system.
ISSN:0030-4018
1873-0310
DOI:10.1016/j.optcom.2005.06.076