Analysis and simulation of a plasmonic biosensor for hemoglobin concentration detection using noble metal nano-particles resonances

• Published in: Optics communications 2020-03, Vol.459, p.124940, Article 124940
• Main Author: Heidarzadeh, Hamid
• Format: Article
• Language: English
• Subjects: Extinction cross-section; Hemoglobin detection; Noble metal; Plasmonic biosensor; Surface plasmon resonance
• ISSN: 0030-4018; 1873-0310
• DOI: 10.1016/j.optcom.2019.124940

In this paper, three different shapes (sphere, cubic, and cylinder) silver plasmonic nano-particles for the detection of hemoglobin concentration in blood is analyzed. This work is done to determine the hemoglobin concentration in blood using a sensing feature by changing hemoglobin concentration from 0 to 140g/l. The impact of hemoglobin concentration on refractive index changes in the surrounding medium of nano-particles is considered. Simulated results show that, scattering cross-section has a sharp peak for cubic nano-particles with the full width at half maximum (FWHM) of 50 nm. FWHM is 64 nm and 94 nm for sphere and cylinder nanoparticles, respectively. Exactly, after applying the hemoglobin refractive index in each concentration to the surrounding medium, an increase in resonance wavelength in extinction cross-section is obtained. The wavelength shifts of 3.3 nm, 3.7 nm, and 5.5 nm are obtained for hemoglobin concentration of 140g/l using sphere, cubic, and cylinder shapes nano-particles, respectively. Further, changing the simulated structure parameters can manage the plasmonic resonance wavelength and it is applicable to detect other biological samples.