Optical emissions of chitosan modified LaAlO3: Bi3+, Tb3+ nanoparticles for bio labeling and drug delivery to breast cancer cells

• Published in: Optical materials 2020-09, Vol.107, p.110162, Article 110162
• Main Authors: Shaik, Esub Basha, Pindiprolu, Sai Kiran S.S., Phanikumar, Chirravuri S., Samuel, T., Kumar, B.V. Naveen, Santhoshi, P. Madhuri, Reddy, P.V.S.S.S.N., Kumar B, Putra, Ramachandra, R.K.
• Format: Article
• Language: English
• Subjects: Breast cancer cells; Cellular internalization; Drug delivery; Luminescence; Nanophosphors
• ISSN: 0925-3467; 1873-1252
• DOI: 10.1016/j.optmat.2020.110162

Nanoparticles with luminescent properties have significant role in cancer theranostics and are extensively used as detection probes and drug carriers. Chitosan (CS) modified LaAlO3:Bi3+, Tb3+ nanophosphors (LNPs) is entrapped with anticancer agent capecitabine (CAP) for target imaging and drug delivery to breast cancer cells. LaAlO3: Bi3+, Tb3+ nanophosphors were synthesized by simple polyol mediated route and characterized by X-ray diffraction, Field emission scanning electron microscopy (FESEM), Energy Dispersive X-ray Analysis (EDAX), High Resolution Transmission Electron Microscopy (HRTEM) and fluorescence spectroscopy. Tb–Bi doped lanthanum aluminate nanoparticles show the typical green luminesce at 544 nm due to the energy transfer from Bi3+ to Tb3+ ions. Bismuth activated Lanthanum aluminate with terbium nanoparticles were then surface modified with CS to improve biocompatibility and facilitate entrapment of anticancer drug CAP. The drug delivery and imaging propensity of CS-CAP-LNPs was assessed in MDA-MB231 (breast cancer) cells. The obtained results demonstrated that CS-CAP-LNPs have greater cellular internalization and significant cytotoxicity (IC50 9 μg/ml) compared to naïve LNPs. The CS-CAP-LNPs, therefore, is a promising multimodal system for therapy and bioimaging of breast cancer. Synthesis of CS-CAP-LNPs; (b) Accumulation of CS-CAP-LNPs at tumor site by EPR effect and internalization of CS-CAP-LNPs in tumor cells. [Display omitted] •LaAlO3: Bi3+, Tb3+ nanophosphors (LNPs) were synthesized and utilized their luminescence properties for targeted drug delivery and bio-imaging of MDA-MB231 cancer cells.•The calculated CIE coordinates evident that the strong green emissions from LaAlO3: Bi3+, Tb3+ nanophosphors are due to terbium ions.•Chitosan (CS), was coated on the LNPs (CS-CAP-LNPs) to improve the cell uptake and entrap anticancer drug capecitabine (CAP).•CS-CAP-LNPs model exhibited greater cytotoxic effect (p