p16 positive oropharyngeal small cell cancer: A case report

Extra-pulmonary small cell carcinomas (EPSCC) are rare malignancies. Like small cell lung cancer (SCLC), they are aggressive malignancies with dismal prognosis. We here report a case of a middle-aged man who presented with odynophagia and cervical lymphadenopathy. Diagnostic workup confirmed the dia...

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Bibliographic Details
Published in:Oral oncology 2021-10, Vol.121, p.105391, Article 105391
Main Authors: Al Masalmeh, Nada, Kukreja, Geetika, Zaiem, Feras, Raza, S. Naweed, Kim, Harold, Nagasaka, Misako, Sukari, Ammar
Format: Article
Language:English
Subjects:
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - virology
Extra-pulmonary small cell carcinoma
HPV
Humans
Male
Middle Aged
Oropharyngeal cancer
Oropharyngeal Neoplasms - diagnosis
Oropharyngeal Neoplasms - virology
Papillomaviridae
Papillomavirus Infections - diagnosis
Small cell carcinoma
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Summary:Extra-pulmonary small cell carcinomas (EPSCC) are rare malignancies. Like small cell lung cancer (SCLC), they are aggressive malignancies with dismal prognosis. We here report a case of a middle-aged man who presented with odynophagia and cervical lymphadenopathy. Diagnostic workup confirmed the diagnosis of locally-advanced p16-positive oropharyngeal cancer (OPC) with a surprising histology of small cell cancer, suggesting a human papilloma virus (HPV)-related oropharyngeal cancer with small cell differentiation. HPV oropharynx infection is a well-known risk factor for squamous cell carcinoma of the oropharynx, but it is unknown if it may increase the risk of other OPC histology.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2021.105391