DEVELOPING RISK PREDICTION MODELS FOR HIP OSTEOARTHRITIS BASED ON AUTOMATED HIP MORPHOLOGY MEASUREMENTS AND EVALUATING ON UNSEEN POPULATIONS: DATA OF THE WORLD COACH CONSORTIUM

• Published in: Osteoarthritis imaging 2024, Vol.4, p.100212, Article 100212
• Main Authors: van den Berg, M.A., Boel, F., van Buuren, M.M.A., Riedstra, N.S., Tang, J., Ahedi, H., Arbabi, V., Arden, N., Bierma-Zeinstra, S.M.A., Boer, C.G., Cicuttini, F.M., Cootes, T.F., Crossley, K.M., Felson, D.T., Gielis, W.P., Heerey, J.J., Jones, G., Kluzek, S., Lane, N.E., Lindner, C., Lynch, J.A., van Meurs, J.B.J., Mosler, A., Nelson, A.E., Nevitt, M.C., Oei, E.H., Runhaar, J., Weinans, H., Krijthe, J.H., Agricola, R.
• Format: Article
• Language: English
• ISSN: 2772-6541; 2772-6541
• DOI: 10.1016/j.ostima.2024.100212

Early identification of hip OA is crucial in enhancing our understanding of HOA development and treatment options. Hip morphology could be a modifiable risk factor for the development of radiographic hip osteoarthritis (RHOA), but the exact risk contribution of hip morphology in the general population remains unclear. By combining individual participant data (IPD) of various studies while considering study heterogeneity, novel modeling techniques could be explored to work towards individualized prediction models. To develop hip morphology based RHOA risk prediction models on multi-cohort datasets and assessed their generalizability to similar and unseen populations. We combined IPD from nine prospective cohort studies collected within the Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH consortium). These studies all had standardized anteroposterior (AP) pelvic, long-limb, and/or hip radiographs taken and graded for RHOA at baseline and 4-8 years follow-up. Risk of incident RHOA was defined as hips with no signs of RHOA at baseline (any RHOA grade