R409 – Apigenin and Kaempferol Effects on Oral Cancer FADU Cells

Problem Dietary flavonoids are being investigated as chemopreventative agents for many cancers. The objective of this study was to determine whether the dietary flavonoids apigenin and kaempferol inhibit growth of malignant oral keratinocytes. Methods FaDu cells were treated with increasing concentr...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2008-08, Vol.139 (2), p.P180-P180
Main Authors: Helton, William B., Choi, Eun-Young, Gairola, C. Gary, Valentino, Joseph, Swanson, Hollie
Format: Article
Language:English
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Summary:Problem Dietary flavonoids are being investigated as chemopreventative agents for many cancers. The objective of this study was to determine whether the dietary flavonoids apigenin and kaempferol inhibit growth of malignant oral keratinocytes. Methods FaDu cells were treated with increasing concentrations of apigenin and kaempferol. After 24 and 48 hours cell growth was determined using the WST-1 assay. Three groups of nude mice (group 1-kaempferol, group 2-apigenin, group 3-controls) were treated by gavage for one week prior to inoculation with FaDu cells (1 × 105 cells) Following inoculation, treatments were continued until sacrifice. Tumor volumes were calculated from three dimensional tumor measurements. Results In vitro cell growth decreased with increasing concentrations of apigenin and kaempferol (p
ISSN:0194-5998
1097-6817
DOI:10.1016/j.otohns.2008.05.563