Caffeine plus nicotine improves motor function, spatial and non-spatial working memory and functional indices in BALB/c male mice

There is a greater prevalence of cigarette smoking among caffeine dependent individuals. This study therefore sought to assess the effect of nicotine and/or caffeine on some key biochemical indices and neurobehavioural parameters associated with brain function in male mice. Forty male BALB/c mice we...

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Bibliographic Details
Published in:Pathophysiology (Amsterdam) 2016-12, Vol.23 (4), p.251-258
Main Authors: Adeniyi, P.A., Omatsuli, E.P., Akinyemi, A.J., Ishola, A.O.
Format: Article
Language:English
Subjects:
Caffeine
Neurotransmitter
Nicotine
Working memory
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Summary:There is a greater prevalence of cigarette smoking among caffeine dependent individuals. This study therefore sought to assess the effect of nicotine and/or caffeine on some key biochemical indices and neurobehavioural parameters associated with brain function in male mice. Forty male BALB/c mice were divided into 4 groups of 10 animals each; Group A serve as the control and received normal saline (s.c), Group B received 2mg/kg body weight of nicotine (s.c), Group C received 2mg/kg body weight of caffeine (s.c) and Group D received 2mg/kg of nicotine and 2mg/kg of caffeine (s.c). The experiment lasted for 21 days, and then the animals were subjected to behavioral test. Thereafter the animals were sacrificed and their brain isolated for the determination of endothelial nitric oxide (NO) level, acetylcholinesterase (AChE), arginase (Arg) and adenosine deaminase (ADA) activities; as well as some antioxidant indices. Administration of nicotine or caffeine caused a significant (P
ISSN:0928-4680
1873-149X
DOI:10.1016/j.pathophys.2016.08.002