Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models

Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2020-06, Vol.193, p.172928, Article 172928
Main Authors: de Abreu, Murilo S., Giacomini, Ana C.V.V., Genario, Rafael, Rech, Nathália, Carboni, Júlia, Lakstygal, Anton M., Amstislavskaya, Tamara G., Demin, Konstantin A., Leonard, Brian E., Vlok, Marli, Harvey, Brian H., Piato, Angelo, Barcellos, Leonardo J.G., Kalueff, Allan V.
Format: Article
Language:English
Subjects:
Acute and chronic stress
Animal model
Animals
Anti-Anxiety Agents - therapeutic use
Antidepressive Agents - therapeutic use
Behavior, Animal - drug effects
Complementary Therapies - methods
Disease Models, Animal
Environmental enrichment
Female
Humans
Male
Mental Disorders - drug therapy
Mental Disorders - etiology
Mental illness
Psychopharmacotherapy
Rodentia
Stress, Psychological - complications
Treatment Outcome
Zebrafish
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Summary:Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2020.172928