Spectral detection of sickle cell anemia and thalassemia

Summary Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common te...

Full description

Saved in:
Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2013-12, Vol.10 (4), p.429-433
Main Authors: Masilamani, V., PhD, Al Salhi, M.S, Devanesan, S, AlGahtani, Farjah H, Abu–Salah, Khalid M, Ahamad, I, Agastian, P
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - diagnosis
Bilirubin - blood
Biliverdine - blood
Biomarkers - blood
Female
Fluorescence spectra
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Male
Photo diagnosis
Porphyrins - blood
Reproducibility of Results
Sensitivity and Specificity
Sickle cell disease and thalassemia
Spectrometry, Fluorescence - methods
Synchronous fluorescence
Thalassemia - blood
Thalassemia - diagnosis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common techniques for detection of these diseases are complete blood cell count, followed by electrophoresis and high performance liquid chromatography. In this connection, the results of this paper indicate the potential of a new technique, based on spectral analysis of blood plasma and cellular components, to detect SCD and Thal with accuracy of 90% and above. To the best of our knowledge this would be the first report on spectral pathology of hemoglobinopathy.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2013.04.001