Loading…

Accompanying photocytotoxic activity of gold nanoechinus and zinc phthalocyanine on cancerous cell lines

•Gold nanoechinus possesses especially high extinction coefficient for both biological windows NIR I and NIR II.•Gold nanoechinus converts the irradiation of 980 nm to 674 nm which is absorbed by Zn phthalocyanine.•The combination of Au NEs and Zn phthalocyanine could be a secure promising modality...

Full description

Saved in:
Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2020-12, Vol.32, p.101929, Article 101929
Main Authors: Sobhani, Nafiseh, Dolat, Elham, Darroudi, Majid, Hashemzadeh, Alireza, Khoobi, Mehdi, Salarabadi, Samaneh Soudmand, Hoseini, Benyamin, Sazgarnia, Ameneh
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Gold nanoechinus possesses especially high extinction coefficient for both biological windows NIR I and NIR II.•Gold nanoechinus converts the irradiation of 980 nm to 674 nm which is absorbed by Zn phthalocyanine.•The combination of Au NEs and Zn phthalocyanine could be a secure promising modality in the treatment of deep-seated tumors. Near-infrared triggered photodynamic therapy (NIR-PDT) has been introduced as a relatively deep tumor treatment modality. The gold Nanoechinus (Au NE) is a rare type of nanostructures that act as a transducer to change NIR wavelength to ultraviolet (UV) and visible lights. During the photodynamic process, Au nanoechinus (Au NE) converts the irradiation of 980 nm to 674 nm which is absorbed by Zn(II) Phthalocyanine tetrasulfonic acid (ZnPcS). In this study the cooperation effect of Au NE and ZnPcS in PDT on MCF7 and Hela cells was investigated. Cytotoxicity and phototoxicity of the composition having different concentrations of Au NE and ZnPcS upon irradiation of 980 nm NIR light were evaluated against MCF7 and Hela cells after two different incubation times and irradiating with two different power densities of laser. Among different experimental groups, in MCF7 cells, which were incubated for 48 h with 50 μg/mL Au NE+2μM ZnPcS and were treated by 980 nm laser with a power density of 200 mW cm−2 for 15 and 30 min, 48 and 38% cell viability were recorded. No appreciable result was observed due to PDT of Hela cells. Comparing to other PDT modalities against MCF7 cells, NIR-PDT procedure suggested in this study with the synergistic effect of Au NE and ZnPcS could be a secure promising modality in the treatment of deep-seated tumors. Carefully increasing the power density and ambient temperature, to the extent of skin tolerance threshold value, seems to be efficient in the treatment of Hela cells.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2020.101929