Successful application of indocyanine green fluorescent imaging for the non-invasive detection of postoperative bile leakage

• Published in: Photodiagnosis and photodynamic therapy 2022-12, Vol.40, p.103132, Article 103132
• Main Authors: Fan, Jun, Li, Xinkai, Peng, Yisheng, Liu, Zhongliang, Chen, Jianfei, Tan, Shunde, Fang, Cheng, Su, Song, Li, Bo, Yang, Xiaoli
• Format: Article
• Language: English
• Subjects: Bile; Bile leakage; Biliary Tract; Case report; Coloring Agents; Contrast Media; Diagnosis; Humans; Indocyanine green; Indocyanine Green - pharmacology; Photochemotherapy - methods
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2022.103132

•Two patients with postoperative bile leakage were successfully identified using indocyanine green fluorescent imaging for the first time.•Indocyanine green fluorescent imaging has high specificity and sensitivity, and no adverse effect to patients, which is helpful for the early diagnosis of postoperative bile leakage and the healing of bile leakage. There is a lack of a simple and reliable method for the diagnosis of postoperative bile leakage. ICG is a water-soluble fluorescent contrast agent. After intravenous injection of ICG, ICG is eventually excreted only through the biliary tract system into the intestines. It is highly sensitive, stable and nonradioactive, and these characteristics provide a theoretical basis for using ICG to diagnose postoperative bile leakage. Two patients with postoperative bile leakage were successfully identified using indocyanine green fluorescent imaging for the first time, suggesting its potential to be a convenient and reliable method for the diagnosis of postoperative bile leakage.