Improvement of surgical scars by early intervention with 5-aminolevulinic acid-mediated photodynamic therapy: A case report

•Photodynamic therapy becomes a possible therapeutic approach for pathological scar.•Low tissue penetration of 5-aminolevulinic acid restricts its therapeutic efficacy.•Incomplete epithelialization at early stage of scarring provide better penetration.•Early intervention of photodynamic therapy is p...

Full description

Saved in:
Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2023-12, Vol.44, p.103811, Article 103811
Main Authors: Yu, Zhixi, Meng, Xinxian, Zhang, Yixin, Zhang, Zheng
Format: Article
Language:English
Subjects:
5-ALA
5-aminolevulinic acid-mediated photodynamic therapy
Early intervention
Photodynamic Therapy
Surgical scar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Photodynamic therapy becomes a possible therapeutic approach for pathological scar.•Low tissue penetration of 5-aminolevulinic acid restricts its therapeutic efficacy.•Incomplete epithelialization at early stage of scarring provide better penetration.•Early intervention of photodynamic therapy is potential strategy for scar prevention. Surgical scar formation afflicts patients and current treatments are limited by inconsistent efficacy, long-term and painful treatment processes. In this report, a patient received 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) on the first postoperative day, once a week for 5 sessions. At two-year follow-up, the intervention of 5-ALA PDT at early stage decreased the vascular density and improved extracellular matrix (ECM) deposition. The early intervention of surgical scar by 5-ALA PDT overcomes the penetration limits of photosensitizer and red light, making it a potential strategy for surgical scar prevention.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2023.103811