Infant botulism, type F, presenting at 54 hours of life

We report a case of botulism in a 54-hour-old infant with rapidly progressive fulminant paralysis and rapid spontaneous recovery atypical for infant botulism. Clostridium baratii and type F botulinum neurotoxin were isolated from the patient’s stool. This unique presentation with rapid recovery is c...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric neurology 2005-03, Vol.32 (3), p.193-196
Main Authors: Keet, Corinne A., Fox, Christine K., Margeta, Marta, Marco, Elysa, Shane, Andi L., DeArmond, Stephen J., Strober, Jonathan B., Miller, Steven P.
Format: Article
Language:English
Subjects:
Acute Disease
Age Factors
Biological and medical sciences
Botulism - microbiology
Botulism - pathology
Botulism - physiopathology
Clostridium botulinum type F
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Human viral diseases
Humans
Infant, Newborn
Infectious diseases
Medical sciences
Neurology
Pregnancy. Fetus. Placenta
Recovery of Function
Severity of Illness Index
Time Factors
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a case of botulism in a 54-hour-old infant with rapidly progressive fulminant paralysis and rapid spontaneous recovery atypical for infant botulism. Clostridium baratii and type F botulinum neurotoxin were isolated from the patient’s stool. This unique presentation with rapid recovery is consistent with pharmacokinetics of type F botulinum neurotoxin. Interestingly, a muscle biopsy also revealed pathologic changes early in the disease course. This article reports the youngest known case of infant botulism and only the third reported case of this disease caused by type F neurotoxin. Botulism should be considered in patients of any age with subacute or acute neuromuscular weakness.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2004.09.003