Dantrolene may prevent organophosphate-induced oxidative stress and muscle injury

The effects of dantrolene against fenthion-induced oxidative stress and muscle injury were investigated in rats. Malondialdehyde (MDA), reduced glutathione (GSH) ascorbic acid, retinol and β-carotene levels in blood were measured. Histopathological alterations and apoptosis in diaphragm were examine...

Full description

Saved in:
Bibliographic Details
Published in:Pesticide biochemistry and physiology 2008-11, Vol.92 (3), p.156-163
Main Authors: Büyükokuroğlu, Mehmet Emin, Cemek, Mustafa, Tosun, Murat, Yürümez, Yusuf, Baş, Orhan, Yavuz, Yücel
Format: Article
Language:English
Subjects:
animal injuries
antioxidants
apoptosis
Biological and medical sciences
cytotoxicity
Dantrolene
enzyme activity
Fenthion
histopathology
laboratory animals
lipid peroxidation
Muscle injury
muscle relaxants
muscles
necrosis
Organophosphate
organophosphorus compounds
Oxidative stress
physiological response
rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of dantrolene against fenthion-induced oxidative stress and muscle injury were investigated in rats. Malondialdehyde (MDA), reduced glutathione (GSH) ascorbic acid, retinol and β-carotene levels in blood were measured. Histopathological alterations and apoptosis in diaphragm were examined. Fenthion increased the level of MDA and decreased the levels of GSH in blood. Dantrolene administration prevented the rise in MDA levels and increased the GSH levels. There was no significant difference between β-carotene levels of experimental groups. However, fenthion toxicity led to decrease in ascorbic acid and retinol levels, dantrolene administration significantly prevented this decrease. Dantrolene significantly decreased the inflammation, edema and muscle necrosis or apoptosis in diaphragm muscle. Results of present study showed that toxicity of organophosphate compound fenthion increases the lipid peroxidation and depresses endogenous antioxidative systems, and leads to muscle injury in organism. Again, dantrolene administration prevents lipid peroxidation, augments antioxidant activity, and decreases muscle injury and apoptosis.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2008.07.012