Plumbagin as a new natural herbicide candidate for Sicyon angulatus control agent with the target 8-amino-7-oxononanoate synthase

A natural compound plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) was isolated from the leaves of Plumbago auriculata and found to inhibit the enzyme, 8-amino-7-oxononanoate synthase (AONS, also known as 7-keto-8-aminopelargonate synthase, KAPAS) an IC50 of 2.1μM in vitro. Biotin supplement signi...

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Bibliographic Details
Published in:Pesticide biochemistry and physiology 2012-07, Vol.103 (3), p.166-172
Main Authors: Choi, Jung-Sup, Park, No-Joong, Lim, Hee-Kyung, Ko, Young-Kwan, Kim, Young-Sup, Ryu, Shi-Yong, Hwang, In-Taek
Format: Article
Language:English
Subjects:
8-Amino-7-oxononanoate synthase
Abutilon theophrasti
Aeschynomene indica
Biological and medical sciences
biotin
Calystegia
Chemical control
Digitaria sanguinalis
Echinochloa crus-galli
foliar application
Fundamental and applied biological sciences. Psychology
grasses
greenhouses
herbicides
inhibitory concentration 50
leaves
Parasitic plants. Weeds
Phytopathology. Animal pests. Plant and forest protection
plant damage
Plumbagin
Plumbago
Plumbago auriculata
riparian areas
rivers
Sicyos angulatus
Solanum nigrum
Sorghum bicolor
vines
Weeds
Xanthium strumarium
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Summary:A natural compound plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) was isolated from the leaves of Plumbago auriculata and found to inhibit the enzyme, 8-amino-7-oxononanoate synthase (AONS, also known as 7-keto-8-aminopelargonate synthase, KAPAS) an IC50 of 2.1μM in vitro. Biotin supplement significantly rescued the plant injury caused by the plumbagin treatment, and this result confirmed the target site, AONS. Foliar application of 1000∼2000μg/mL plumbagin in a greenhouse condition showed lethal activity against eight species of weeds, containing three grass species of Sorghum bicolor, Echinochloa crus-galli, Digitaria sanguinalis and five broad leaf species of Solanum nigrum, Aeschynomene indica, Abutilon avicennae, Xanthium strumarium, Calystegia japonica. Field trial of foliar application with plumbagin 2000μg/mL have successfully controlled 10∼15 leaf-stages and 2∼3m vine lengths of Sicyos angulatus at the natural habitats around riparian zone in the Nam-Han River in Korea. Visual symptom of desiccation might be induced by the physiological cellular leakage which was significantly dose dependent on the plumbagin treatment regardless of light.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2012.04.007