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On the biochemical and molecular mechanisms by which malathion induces dysfunction in pancreatic islets in vivo and in vitro

[Display omitted] •Pancreatic endocrine system is affected in acute poisoning with malathion.•Malathion impairs glucose metabolism by increasing oxidative stress markers.•Impairment of glucose metabolism is critical in dysfunction of insulin induced by malathion. Recent studies showed that organopho...

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Published in:Pesticide biochemistry and physiology 2013-05, Vol.106 (1-2), p.51-60
Main Authors: Nili-Ahmadabadi, Amir, Pourkhalili, Nazila, Fouladdel, Shamileh, Pakzad, Mohsen, Mostafalou, Sara, Hassani, Shokoufeh, Baeeri, Maryam, Azizi, Ebrahim, Ostad, Seyed Nasser, Hosseini, Rohollah, Sharifzadeh, Mohammad, Abdollahi, Mohammad
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Language:English
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Summary:[Display omitted] •Pancreatic endocrine system is affected in acute poisoning with malathion.•Malathion impairs glucose metabolism by increasing oxidative stress markers.•Impairment of glucose metabolism is critical in dysfunction of insulin induced by malathion. Recent studies showed that organophosphorus pesticides can increase incidence of metabolic disorders and diabetes. Considering the importance of pancreas in regulating blood glucose, the effect of malathion on essential elements of glucose-stimulated insulin secretion (GSIS) in in vitro and in vivo conditions were evaluated. After dividing of rats into control and treatment groups, oral glucose tolerance test (OGTT) was examined and then kinetic of glucose as well as pancreatic response to raise blood glucose were evaluated. After isolation of islets from pancreas, its function as well as oxidative stress markers and essential elements of GSIS were examined. Malathion at dose of 400mg/kg impaired GTT and increased AUC0–180min (P=0.047) and T1/2β of glucose (P=0.0016), and reduced insulin response (P=0.005) 30min after oral administering of glucose. In addition to impaired glucose tolerance, there were significant increases in lipid peroxidation (P
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2013.04.003