Comparison of two liquid nutritional supplements designed for patients with diabetes: Effect on glucose and insulin metabolism in healthy subjects

• Published in: PharmaNutrition 2015-01, Vol.3 (1), p.7-10
• Main Authors: González-Ortiz, Manuel, Martínez-Abundis, Esperanza, Robles-Cervantes, José Antonio, Pérez-Rubio, Karina Griselda
• Format: Article
• Language: English
• Subjects: Diabetes mellitus; Insulin secretion; Insulin sensitivity; Nutritional supplements
• ISSN: 2213-4344; 2213-4344
• DOI: 10.1016/j.phanu.2014.11.002

[Display omitted] •Liquid nutritional supplements designed for the patient with diabetes mellitus have been an alternative to achieve, in some cases, the amount and proportion of recommended nutrients.•Liquid nutritional supplements have shown different effects on glucose and insulin metabolism, which could impact on metabolic control.•Scarce information exists about the effect of liquid nutritional supplements for diabetic patients on glucose and insulin metabolisms. To compare the effect of the single administration of two liquid nutritional supplements designed for diabetic patients and administered to healthy subjects to determine glucose and insulin metabolism. A randomized, double-blind, crossover clinical trial as a pilot study was carried out in 10 healthy young volunteers. Each individual received a single administration of Enterex Diabetic or Boost GC. At the beginning of each administration and after 30, 60, 90 and 120min, glucose and insulin concentrations were measured. Area under the curve (AUC) of glucose and insulin was calculated. First phase (Stumvoll index) and total insulin secretion (insulinogenic index) as well as insulin sensitivity (Matsuda index) were assessed. Boost GC compared with Enterex Diabetic showed a lower AUC of glucose (9496±897 vs. 10,996±842mg/dl, p=0.004), AUC of insulin (2253±910 vs. 3924±1468, p=0.008) and Stumvoll index (1160±233 vs. 1384±295, p=0.049) as well as a higher Matsuda index (31.2±39.5 vs. 9.9±2.6, p=0.001). A single administration of Boost GC in healthy individuals showed lower insulin secretion and higher insulin sensitivity compared with Enterex Diabetic.